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KMID : 0365819710110010053
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Journal of Pusan Medical College
1971 Volume.11 No. 1 p.53 ~ p.63
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A Study of the Sodium and Potassium Activated Adenosinetriphosphatase Activity of Ciliary Process Mitochondrial Fraction
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Abstract
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The author investigated the effect of ouabain, acetazolamide, pilocarpine, physostigmine, prednisolone and hydrocortisone on the Na+-and K+-activated ATPase activity of mitochondrial fraction isolated from bovine ciliary process.
The conclusions were as follows:
1. The mitochondrial fraction was found to contain the Na+-K+-activated ATPase in the presence of Mg++.
2. The ATPase activity was greatest at the Na+ concentration of 100 mM as well as at K+ concentration of 10mM.
3. The ATPase activity was appeared to be optimum in the range of pH 7.0 to 10.0.
4. The ATPase activity was depressed by cardiac glycoside such as ouabain, diuretic such as aceta
zolamide and cholinergic drugs such as pilocarpine and physostigmine.
5. The ATPase activity was increased by steroid hormones such as prednisolone and hydrocortisone. 6. These findings were suggestive that the nature of ATPase isolated from the mitochondrial fraction of bovine ciliary process was quite similar to that from other organs such as the heart and skeletal muscles although there are certain features specific to the type of organs.
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